C3a (70-77) TFA (63555-63-5 free base) ( Complement 3a (70-77) (TFA) )

Catalog No. M29892 CAS No.

COA

Datasheet

HNMR

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MSDS

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Product Name

C3a (70-77) TFA (63555-63-5 free base)
Note

Research use only, not for human use.
Brief Description

C3a (70-77) TFA (Complement 3a (70-77) TFA) is a COOH-terminal fragment of the C3a anaphylatoxin peptide.
Description

C3a (70-77) TFA (Complement 3a (70-77) TFA) is a COOH-terminal fragment of the C3a anaphylatoxin peptide.(In Vitro):The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. The cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites.
Synonyms

Complement 3a (70-77) (TFA)
Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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Payan DG, et al. Modulation of human lymphocyte function by C3a and C3a(70-77). J Exp Med. 1982 Sep 1;156(3):756-65.

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